Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process the digitalis glycoside more quickly.
What might happen:
Your blood levels of your digitalis glycoside may decrease and cause a decrease in its beneficial effects.
What you should do about this interaction:
Contact your doctor if you experience increased heartbeat; swelling of your ankles, feet, or hands; or breathing problems. It may be necessary to adjust the dose of your medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Rameis H. On the interaction between phenytoin and digoxin. Eur J Clin Pharmacol 1985;29(1):49-53.
2.Perrier D, Mayersohn M, Marcus FI. Clinical pharmacokinetics of digitoxin. Clin Pharmacokinet 1977 Jul-Aug;2(4):292-311.
3.Helfant RH, Scherlag BJ, Damato AN. The electrophysiological properties of diphenylhydantoin sodium as compared to procaine amide in the normal and digitalis-intoxicated heart. Circulation 1967 Jul;36(1):108-18.
4.Lanoxin (digoxin) Tablets US prescribing information. Covis Pharmaceuticals, Inc. July, 2015.