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    Phenytoin Suspension, (Final Dose Form)

    Interactions

    Posaconazole/Selected Anticonvulsants

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    Some anticonvulsants such as carbamazepine, phenobarbital, phenytoin, and primidone may speed up how quickly your liver processes posaconazole.In addition, posaconazole may slow down how quickly your liver processes carbamazepine or phenytoin.

    What might happen:

    The amount of posaconazole in your blood may decrease and it may not work as well. The amount of carbamazepine or phenytoin in your blood may increase and cause adverse effects.

    What you should do about this interaction:

    Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your doctor may need to check the blood levels of one or both medicines to be sure they are in a safe and effective range. The dose of your posaconazole, and/or your anticonvulsant medicine may need to be adjusted.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

    References:

    1.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc September, 2016.

    2.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. February 2, 2006.

    3.Anderson Gail D. Chapter 42: Pharmacokinetics and Drug Interactions. In: Wyllie's Treatment of Epilepsy: Principles and Practice, 5th Ed. 2011.

    4.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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