Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Taking these two medicines together may speed up how quickly your liver processes your blood pressure medicine.
What might happen:
The beneficial effects of your blood pressure medicine may be decreased.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check your blood pressure more often and may want to change your blood pressure medicine.Contact your doctor if you have an increase in blood pressure or experience blurred vision, dizziness, or headaches.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sular (nisoldipine) US prescribing information. Shionogi, Inc. December, 2012.
2.Michelucci R, Cipolla G, Passarelli D, Gatti G, Ochan M, Heinig R, Tassinari CA, Perucca E. Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. Epilepsia 1996 Nov; 37(11):1107-10.