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phenytoin

Interactions

Phenytoin/Eslicarbazepine; Oxcarbazepine (mono deleted 04/17/2014)

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Eslicarbazepine or oxcarbazepine may slow down how quickly your liver processes phenytoin. Phenytoin may speed up how quickly your liver processes eslicarbazepine or oxcarbazepine.

What might happen:

The amount of phenytoin in your blood may increase and cause more side effects. The amount of eslicarbazepine or oxcarbazepine in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any nausea, vomiting, confusion, dizziness, or if have more seizures than normal.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Trileptal (oxcarbazepine) US prescribing information. Novartis Pharmaceuticals Corporation July, 2014.

2.Lakehal F, Wurden CJ, Kalhorn TF, Levy RH. Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19. Epilepsy Res 2002 Dec;52(2):79-83.

3.Aptiom (eslicarbazepine) US prescribing information. Sunovian Pharmaceuticals Inc. November, 2013.

4.McKee PJ, Blacklaw J, Forrest G, Gillham RA, Walker SM, Connelly D, Brodie MJ. A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients. Br J Clin Pharmacol 1994 Jan;37(1):27-32.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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