Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Boceprevir and telaprevir may slow down how quickly your body processes digoxin.
What might happen:
Your blood levels of digoxin may increase causing loss of appetite, nausea, vomiting, diarrhea, headache, weakness, blurred vision, confusion, and a fast or slow or irregular heartbeat.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Notify your doctor if you are experiencing nausea, vomiting, diarrhea, loss of appetite, fast or slow or irregular heartbeat, or vision changes (e.g. blurred vision or yellow/green halos around objects). You may need to have your blood level of digoxin checked, and your dose may need to be adjusted.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Victrelis (boceprevir) US prescribing information. Schering Corporation February, 2014.
2.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.
3.Garg V, Chandorkar G, Farmer HF, Smith F, Alves K, van Heeswijk RP. Effect of Telaprevir on the Pharmacokinetics of Midazolam and Digoxin. J Clin Pharmacol 2012 Jan 26.