Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Ezogabine may slow down how quickly your body processes digoxin.
What might happen:
Your blood levels of digoxin may increase causing loss of appetite, nausea, vomiting, diarrhea, headache, weakness, blurred vision, confusion, and a fast or slow or irregular heartbeat.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Notify your doctor if you are experiencing nausea, vomiting, diarrhea, loss of appetite, unusual fatigue, fast or slow or irregular heartbeat, or vision changes (e.g. blurred vision or yellow/green halos around objects). You may need to have your blood level of digoxin checked, and your dose may need to be adjusted.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.FDA. Ezogabine CDER Drug Approval Package, Application: 022345, Approval Date:06/10/2011. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022345Orig1s000TOC. cfm June 10, 2011.
2.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline August, 2012.
3.Potiga (ezogabine) US Prescribing Information. Valeant Pharmaceuticals September, 2013.