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Serzone

Interactions

Conivaptan; Tolvaptan/Strong CYP3A4 Inhibitors

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may slow down how quickly your liver processes conivaptan and tolvaptan.

What might happen:

The amount of conivaptan or tolvaptan in your body may build up and cause more side effects than normal.

What you should do about this interaction:

Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are taking these two medications together.Contact your healthcare professional right away if you begin feeling dizzy, drowsy, or confused; are more thirsty than usual; have trouble speaking or swallowing; or have any mood changes, trouble controlling body movements, weakness in the arms or legs, or seizures.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Vaprisol (conivaptan hydrochloride) US prescribing information. Astellas Pharma US, Inc. February, 2012.

2.Samsca (tolvaptan) US prescribing information. Otsuka Pharmaceutical Co., Ltd. February, 2014.

3.Samsca (tolvaptan) US prescribing information. Otsuka Pharmaceutical Co., Ltd. November, 2012.

4.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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