Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Bicalutamide may slow down how quickly your liver processes cisapride
What might happen:
The amount of cisapride in your blood may increase. This may cause an irregular heartbeat, which may be life threatening.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Let your doctor know right away if you notice an irregular heartbeat or have dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Casodex (bicalutamide) UK summary of product characteristics. AstraZeneca UK Limited November 13, 2007.