Skip to content
My WebMD Sign In, Sign Up
Mi-Acid

Interactions

Oral Iron Supplements/Selected Minerals

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Iron may bind to other minerals in your GI tract, which may prevent them from being absorbed.

What might happen:

The amount of minerals you absorb from your supplement may decrease.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Do not take your iron supplement within 1 hour before or 2 hours after products containing calcium, manganese, tin, or zinc. Your doctor may want to check your blood to see if your levels of iron or other minerals are low.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Ferrous gluconate US prescribing information. GFR Nutritionals Ltd September 29, 2003.

2.Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr 1991 Jan;53(1):106-11.

3.Pruchnicki MC, Coyle JD, Hoshaw-Woodard S, Bay WH. Effect of phosphate binders on supplemental iron absorption in healthy subjects. J Clin Pharmacol 2002 Oct;42(10):1171-6.

4.Rossander-Hulten L, Brune M, Sandstrom B, Lonnerdal B, Hallberg L. Competitive inhibition of iron absorption by manganese and zinc in humans. Am J Clin Nutr 1991 Jul;54(1):152-6.

5.Valberg LS, Flanagan PR, Chamberlain MJ. Effects of iron, tin, and copper on zinc absorption in humans. Am J Clin Nutr 1984 Sep;40(3):536-41.

6.Solomons NW, Jacob RA. Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. Am J Clin Nutr 1981 Apr;34(4):475-82.

7.Friel JK, Serfass RE, Fennessey PV, Miller LV, Andrews WL, Simmons BS, Downton GF, Kwa PG. Elevated intakes of zinc in infant formulas don not interfere with iron absorption in premature infants. J Pediatr Gastroenterol Nutr 1998 Sep;27(3):312-6.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

URAC: Accredited Health Web Site HONcode Seal AdChoices