Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, rifampin may interfere with the way your body processes your antifungal medicine. Also, your antifungal medicine may interfere with the way your body processes rifampin.
What might happen:
The anti-infective effects of both your antifungal medicine and your rifampin may decrease.
What you should do about this interaction:
If signs of your infection do not improve or worsen, contact your doctor. It may be necessary to adjust the dose of your antifungal medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
1.Brass C, Galgiani JN, Blaschke TF, Defelice R, O'Reilly RA, Stevens DA. Disposition of ketoconazole, an oral antifungal, in humans. Antimicrob Agents Chemother 1982 Jan;21(1):151-8.
2.Drouhet E, Dupont B. Laboratory and clinical assessment of ketoconazole in deep-seated mycoses. Am J Med 1983 Jan 24;74(1B):30-47.
3.Engelhard D, Stutman HR, Marks MI. Interaction of ketoconazole with rifampin and isoniazid. N Engl J Med 1984 Dec 27;311(26):1681-3.
4.Meunier F. Serum fungistatic and fungicidal activity in volunteers receiving antifungal agents. Eur J Clin Microbiol 1986 Feb;5(1):103-9.
5.Doble N, Shaw R, Rowland-Hill C, Lush M, Warnock DW, Keal EE. Pharmacokinetic study of the interaction between rifampicin and ketoconazole. J Antimicrob Chemother 1988 May;21(5):633-5.
6.Abadie-Kemmerly S, Pankey GA, Dalovisio JR, Dalvisio JR. Failure of ketoconazole treatment of Blastomyces dermatitidis. Ann Intern Med 1988 Nov 15;109(10):844-5.
7.Blomley M, Teare EL, de Belder A, Thway Y, Weston M. Itraconazole and anti-tuberculosis drugs. Lancet 1990 Nov 17;336(8725):1255.
8.Coker RJ, Tomlinson DR, Parkin J, Harris JR, Pinching AJ. Interaction between fluconazole and rifampicin. BMJ 1990 Oct 6;301(6755):818.
9.Apseloff G, Hilligoss DM, Gardner MJ, Henry EB, Inskeep PB, Gerber N, Lazar JD. Induction of fluconazole metabolism by rifampin: in vivo study in humans. J Clin Pharmacol 1991 Apr;31(4):358-61.
10.Tucker RM, Denning DW, Hanson LH, Rinaldi MG, Graybill JR, Sharkey PK, Pappagianis D, Stevens DA. Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clin Infect Dis 1992 Jan;14(1):165-74.