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clozapine

Interactions

Clozapine/Ciprofloxacin

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Ciprofloxacin may slow down how quickly your liver processes clozapine.

What might happen:

The amount of clozapine in your blood may increase and cause more side effects, such as a fast heartbeat, weakness, fatigue, dizziness, increased salivation, or decreased breathing.

What you should do about this interaction:

If you notice an increase in side effects, notify your healthcare professionals (e.g. doctor or pharmacist). Your doctor may want to change the dose of your clozapine while you are taking ciprofloxacin, or your doctor may want to change your antibiotic.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Raaska K, Neuvonen PJ. Ciprofloxacin increases serum clozapine and N-desmethylclozapine: a study in patients with schizophrenia. Eur J Clin Pharmacol 2000 Nov;56(8):585-9.

References:

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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