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glyburide micronized

Interactions

Sulfonylureas/Ethyl Alcohol

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Alcohol lowers blood glucose levels and disrupts the product of glucose in the liver.

What might happen:

Consuming alcohol with your medicine may lead to hypoglycemia, a condition in which your blood glucose levels are too low. Symptoms of low blood sugar include pale skin, blurred vision, loss of consciousness, increased thirst, increased urination, blurred vision, fatigue, or fast, deep breathing.Your diabetic medicine may also make you intolerant to alcohol. Symptoms of alcohol intolerance include flushing, throbbing in the head and neck, irregular heart beat, rapid heart beat, low blood pressure, sweating, nausea, and vomiting.

What you should do about this interaction:

Avoid drinking alcohol. Alcohol is also contained in many medicines. Discuss the amount of alcohol in your medicines with your healthcare (e.g. doctor or pharmacist).If you notice any signs or symptoms of low blood sugar or alcohol intolerance, contact your healthcare professional. Your doctor may want you to check your blood sugar more frequently or adjust your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Arky RA, Veverbrants E, Abramson EA. Irreversible hypoglycemia. A complication of alcohol and insulin. JAMA 1968 Oct 14;206(3):575-8.

2.Dornhorst A, Ouyang A. Effect of alcohol on glucose tolerance. Lancet 1971 Oct 30;2(7731):957-9.

3.Jackson JE, Bressler R. Clinical pharmacology of sulphonylurea hypoglycaemic agents: part 2. Drugs 1981 Oct;22(4):295-320.

4.Walsh CH, O'Sullivan DJ. Effect of moderate alcohol intake on control of diabetes. Diabetes 1974 May;23(5):440-2.

5.Barnett AH, Gonzalez-Auvert C, Pyke DA, Saunders JB, Williams R, Dickenson CJ, Rawlins MD. Blood concentrations of acetaldehyde during chlorpropamide-alcohol flush. Br Med J (Clin Res Ed) 1981 Oct 10; 283(6297):939-41.

6.Shah MN, Clancy BA, Iber FL. Comparison of blood clearance of ethanol and tolbutamide and the activity of hepatic ethanol-oxidizing and drug-metabolizing enzymes in chronic alcoholic subjects. Am J Clin Nutr 1972 Feb;25(2):135-9.

7.Iber FL. Drug metabolism in heavy consumers of ethyl alcohol. Clin Pharmacol Ther 1977 Nov;22(5 Pt 2):735-42.

8.Kater RM, Tobon F, Iber FL. Increased rate of tolbutamide metabolism in alcoholic patients. JAMA 1969 Jan 13;207(2):363-5.

9.Medbak S, Wass JA, Clement-Jones V, Cooke ED, Bowcock SA, Cudworth AG, Rees LH. Chlorpropamide alcohol flush and circulating met-enkephalin: a positive link. Br Med J (Clin Res Ed) 1981 Oct 10;283(6297):937-9.

10.Leslie RD, Pyke DA. Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes. Br Med J 1978 Dec 2; 2(6151):1519-21.

11.Kobberling J, Bengsch N, Bruggeboes B, Schwarck H, Tillil H, Weber M. The chlorpropamide alcohol flush. Lack of specificity for familial non-insulin dependent diabetes. Diabetologia 1980 Oct;19(4):359-63.

12.deSilva NE, Tunbridge WM, Alberti KG. Low incidence of chlorpropamide-alcohol flushing in diet-treated, non-insulin-dependent diabetes. Lancet 1981 Jan 17;1(8212):128-31.

13.Strakosch CR, Jefferys DB, Keen H. Blockade of chlorpropamide alcohol flush by aspirin. Lancet 1980 Feb 23;1(8165):394-6.

14.Leslie RD, Bellamy D, Pyke DA. Asthma induced by enkephalin. Br Med J 1980 Jan 5;280(6206):16-8.

15.Barnett AH, Pyke DA. Chlorpropamide-alcohol flushing and large-vessel disease in non-insulin-dependent diabetes. Br Med J 1980 Jul 26; 281(6235):261-2.

16.Harris EL. Adverse reactions to oral antidiabetic agents. Br Med J 1971 Jul 3;3(765):29-30.

17.Capretti L, Speroni G, Girone M, Coscelli C, Butturini U, Rocca G. Chlorpropamide- and tolbutamide-alcohol flushing in non-insulin-dependent diabetes. Br Med J (Clin Res Ed) 1981 Nov 21;283(6303):1361-2.

18.Wardle EN, Richardson GO. Alcohol and glibenclamide. Br Med J 1971 Jul 3; 3:309.

19.FITZGERALD MG, GADDIE R, MALINS JM, O'SULLIVANDJ. Alcohol sensitivity in diabetics receiving chlorpropromide. Diabetes 1962 Jan-Feb;11:40-3.

20.McKendry JB, Gfeller KF. Clinical experience with the oral antidiabetic compound, tolazamide. Can Med Assoc J 1967 Mar 4;96(9):531-5.

21.USFood and Drug Administration (FDA). Docetaxel: Drug Safety Communication - May Cause Symptoms of Alcohol Intoxication. available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHuman MedicalProducts/ucm402106.htm June 20, 2014.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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