Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
When these two medicines are taken close together, they may reduce your kidney function and decrease the amount of urine that you produce.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. It may be necessary to separate your doses of these medicines by several days. Contact your doctor as soon as possible if you notice a decrease in the amount of urine; bloating; or swelling of the ankles, feet, or hands. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Price P, Thompson H, Bessell EM, Bloom HJ. Renal impairment following the combined use of high-dose methotrexate and procarbazine. Cancer Chemother Pharmacol 1988;21(3):265-7.