How the interaction occurs:
These two medicines are taken together to help lower your blood pressure. In some people, they may increase blood pressure. If you stop taking clonidine and continue taking your beta-blocker, or if you stop taking them both at the same time, your blood pressure may also increase.
What might happen:
Your blood pressure may increase to a dangerous level, causing headache, nausea, vomiting, flushing, confusion, tremor, irritability with unrest, or a fast or irregular heartbeat.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. You may need to check your blood pressure more often when starting or stopping these medicines. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Follow closely any instructions that your doctor gives you about stopping these medicines.
1.Bailey RR, Neale TJ. Rapid clonidine withdrawal with blood pressure overshoot exaggerated by beta-blockade. Br Med J 1976 Apr 17; 1(6015):942-3.
2.Strauss FG, Franklin SS, Lewin AJ, Maxwell MH. Withdrawal of antihypertensive therapy. Hypertensive crisis in renovascular hypertension. JAMA 1977 Oct 17;238(16):1734-6.
3.Vernon C, Sakula A. Fatal rebound hypertension after abrupt withdrawal of clonidine and propranolol. Br J Clin Pract 1979 Apr;33(4):112, 121.
4.Bruce DL, Croley TF, Lee JS. Preoperative clonidine withdrawal syndrome. Anesthesiology 1979 Jul;51(1):90-2.
5.Warren SE, Ebert E, Swerdlin AH, Steinberg SM, Stone R. Clonidine and propranolol paradoxical hypertension. Arch Intern Med 1979 Feb;139(2):253.
6.Lilja M, Jounela AJ, Juustila H, Mattila MJ. Interaction of clonidine and beta-blockers. Acta Med Scand 1980;207(3):173-6.
7.Garvey HL, Woodhouse BL. Reversal of clonidine-induced hypotension by beta-adrenoceptor blocking drugs. Eur J Pharmacol 1980 Jul 11;65(1):55-62.
8.Rosenthal T, Rabinowitz B, Boichis H, Elazar E, Brauner A, Neufeld HN. Use of labetalol in hypertensive patients during discontinuation of clonidine therapy. Eur J Clin Pharmacol 1981;20(4):237-40.
9.Cummings DM, Vlasses PH. Antihypertensive drug withdrawal syndrome. Drug Intell Clin Pharm 1982 Nov;16(11):817-22.
10.Lilja M. Interaction of clonidine and labetalol in hypertension. Acta Med Scand 1983;214(2):119-24.
11.Jounela AJ, Lilja M. Interactions between beta-blockers and clonidine. Ann Clin Res 1984;16(4):181-2.