Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Boceprevir and telaprevir may slow down how quickly your liver processes ergot derivatives.
What might happen:
The amount of ergot derivative in your blood may increase. This may decrease blood flow to your extremities (arms, legs, and/or face).
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. If you experience chest pain; change in heartbeat; numbness and tingling of your hands, feet, or face; pain in your arms, legs, or lower back; itching; or other symptoms while taking these medicines together, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Victrelis (boceprevir) US prescribing information. Schering Corporation July, 2014.
2.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.