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Aerolate 111

Interactions

Theophyllines/Disulfiram

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, disulfiram may prevent your body from processing theophyllines properly.

What might happen:

Your blood level of theophylline may increase and cause toxic effects.

What you should do about this interaction:

If you experience abdominal pain, confusion, seizures, diarrhea, dark or bloody vomit, dizziness, fast or irregular heartbeat, or nervousness, contact your healthcare professional (e.g. doctor or pharmacist). Your doctor may want to measure the amount of theophylline in your blood and may adjust the dose.Your healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Loi CM, Day JD, Jue SG, Bush ED, Costello P, Dewey LV, Vestal RE. Dose-dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics. Clin Pharmacol Ther 1989 May;45(5):476-86.

References:

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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