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Zestoretic

Interactions

Diazoxide/Thiazide Diuretics

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, diazoxide changes the way the body handles the thiazide diuretics.

What might happen:

Your blood sugar may be increased more than expected.

What you should do about this interaction:

Your blood sugar should be carefully monitored when taking these medicines together.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Dollery CT, Pentecost BL, Samaan NA. Drug-induced diabetes. Lancet 1962 Oct 13;2:735-7.

2.Okun R. Use of diazoxide with trichlormethiazide for hypertension. Arch Int Med 1963 Dec;112(6):882-8.

3.Ernesti M, Mitchell ML, Raben MS, Gilboa Y. Control of hypoglycaemia with diazoxide and human growth hormone. Lancet 1960 Mar 20;1:628-30.

4.Seltzer HS, Allen EW. Hyperglycemia and inhibition of insulin secretion during administration of diazoxide and trichlormethiazide in man. Diabetes 1969 Jan;18(1):19-28.

5.Sellers EM, Koch-Weser J. Protein binding and vascular activity of diazoxide. N Engl J Med 1969 Nov 20;281(21):1141-5.

6.Hypotensive Agents (diazoxide) 24:08. In AHFS Drug Information. Bethesda MD: American Society of Health-System Pharmacists, Inc. 1994.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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