Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process theophylline properly.
What might happen:
The effects of your theophylline may increase and cause toxic effects.
What you should do about this interaction:
If you experience headache, nausea, nervousness, or other symptoms, contact your healthcare professional (e.g. doctor or pharmacist). Your doctor may want to adjust the dose of your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Awni WM, Braeckman RA, Granneman GR, Witt G, Dube LM. Pharmacokinetics and pharmacodynamics of zileuton after oral administration of single and multiple dose regimens of zileuton 600mg in healthy volunteers. Clin Pharmacokinet 1995;29 Suppl 2:22-33.
2.Zyflo (zileuton) US prescribing information. Cornerstone Therapeutics, Inc. November, 2011.