How the interaction occurs:
Ciprofloxacin may decrease the ability of your kidneys to remove methotrexate from your body.
What might happen:
The amount of methotrexate in your body may increase, which may cause more serious, potentially life threatening side effects.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your doctor may want to monitor the amount of methotrexate in your blood, change the dose of your methotrexate, or change your antibiotic medicine. Let your doctor know right away if you develop nausea, stomach pain, yellowing of the eyes or skin, dark urine, fever, fatigue, a persistent sore throat, easy bruising or bleeding, black stools, a change in the amount of urine you pass, skin rash, breathing problems, dry cough, diarrhea, or mouth sores while taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Cipro (ciprofloxacin hydrochloride) US prescribing information. Bayer Corporation August, 2013.
2.Methotrexate (tablets, injection) Canada prescribing information. Pfizer Canada Inc. April 21, 2011.
3.Dalle JH, Auvrignon A, Vassal G, Leverger G. Interaction between methotrexate and ciprofloxacin. J Pediatr Hematol Oncol 2002 May; 24(4):321-2.