Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process methotrexate or pralatrexate properly.
What might happen:
Your blood levels of methotrexate or pralatrexate may increase and cause easy bruising or bleeding, persistent sore throat or fever, or fatigue. These effects are more likely if you are taking a high dose of methotrexate, such as those used in the treatment of cancer or psoriasis.
What you should do about this interaction:
Contact your doctor as soon as possible if you are taking these two medicines. Your doctor may monitor your methotrexate or pralatrexate blood levels and the dosage may need to be adjusted.If you feel unusually drowsy, have blurred vision, headaches, stomach pain, fever, chills, rashes, mouth sores, nausea or vomiting, contact your doctor.Make sure that your doctor knows all of the medicines that you are taking. Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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