Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, metoclopramide may block the effects of cabergoline or pergolide.
What might happen:
The effectiveness of your cabergoline or pergolide may be decreased.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Dostinex (cabergoline) US prescribing information. Pfizer August, 2011.
2.Celance (pergolide mesylate) UK summary of product characteristics. Eli Lilly and Company 1997.
3.Permax (pergolide) US prescribing information. Eli Lilly and Company July 12, 2004.