Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may absorb less of your seizure medicine.
What might happen:
The effects of your seizure medicine may decrease.
What you should do about this interaction:
Contact your doctor if you experience any seizures.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. It may be necessary to adjust the dosage of your seizure medicine. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Smart HL, Somerville KW, Williams J, Richens A, Langman MJ. The effects of sucralfate upon phenytoin absorption in man. Br J Clin Pharmacol 1985 Sep; 20(3):238-40.
2.Hall TG, Cuddy PG, Glass CJ, Melethil S. Effect of sucralfate on phenytoin bioavailability. Drug Intell Clin Pharm 1986 Jul-Aug;20(7-8):607-11.