Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Febuxostat may slow down how quickly your body processes azathioprine and mercaptopurine.
What might happen:
The amount of these medicines may increase and cause toxic effects such as fever, chills, easy bruising or bleeding, black or tarry stools, blood in urine, or mouth or lip sores.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Let your doctor know right away if you develop fever, chills, easy bruising or bleeding, black or tarry stools, blood in urine, or mouth or lip sores.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Uloric (febuxostat) US prescribing information. Takeda Pharmaceuticals America, Inc. November, 2011.
2.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.