How the interaction occurs:
When these two medicines are taken together, valproic acid may decrease the ability of your body to process lamotrigine properly.
What might happen:
Your blood levels of lamotrigine may increase and cause a life-threatening rash. Your blood levels of valproic acid may also decrease when you first start taking these medicines together.
What you should do about this interaction:
If you experience a rash of any kind, contact your doctor immediately. Your doctor may need to adjust the dose of your lamotrigine or valproic acid. This rash is more common in children.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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