Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When you take these two medicines together, your body may not process your asthma medicine properly.
What might happen:
Your blood level of asthma medicine may increase and cause toxic effects.
What you should do about this interaction:
If you experience chest pain, rapid or irregular heartbeat, confusion, loss of appetite, nausea, vomiting, or breathing difficulties, contact your doctor. Your doctor may need to adjust the dose of your asthma medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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2.Chen TW, Patton TF. Effect of probenecid on the pharmacokinetics of aminophylline. Drug Intell Clin Pharm 1983 Jun;17(6):465-6.