Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both procainamide and amiodarone can affect your heart rhythm.
What might happen:
These medicines may be used together to help keep your heart rhythm stable. However, there is also a chance that the combination may increase your risk for an irregular heartbeat, which may be very serious.
What you should do about this interaction:
Make sure your cardiologist (heart doctor) knows you are taking these medicines together. Also make sure your doctor knows all the other medicines you are taking. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your doctor may want to perform tests of your heart function, check blood levels of your medicine, and may want to adjust the dose of one or both medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Windle J, Prystowsky EN, Miles WM, Heger JJ. Pharmacokinetic and electrophysiologic interactions of amiodarone and procainamide. Clin Pharmacol Ther 1987 Jun;41(6):603-10.
2.Cordarone (amiodarone hydrochloride) US prescribing information. Wyeth Pharmaceuticals March, 2015.
3.Saal AK, Werner JA, Greene HL, Sears GK, Graham EL. Effect of amiodarone on serum quinidine and procainamide levels. Am J Cardiol 1984 May 1; 53(9):1264-7.
4.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
5.Marchlinski FE, Buxton AE, Kindwall KE, Miller JM, Rosenthal ME, Gottlieb CD, Bloom RB, Josephson ME. Comparison of individual and combined effects of procainamide and amiodarone in patients with sustained ventricular tachyarrhythmias. Circulation 1988 Sep;78(3):583-91.
6.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.