Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, the vaccine may not work as well.
What might happen:
The vaccine may be ineffective.
What you should do about this interaction:
Before receiving a vaccination, let your doctor know if you are taking mefloquine or are going to start taking medicine to prevent malaria.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Lariam (mefloquine hydrochloride) US prescribing information. Roche Pharmaceuticals August, 2009.