Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, the vaccine may not work as well.
What might happen:
The vaccine may be ineffective.
What you should do about this interaction:
Before receiving a vaccination, let your doctor know if you are taking mefloquine or are going to start taking medicine to prevent malaria.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Lariam (mefloquine hydrochloride) US prescribing information. Roche Pharmaceuticals August, 2009.
2.Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR January 28, 2011;60(RR No.2):1-64.
3.Vivotif (typhoid vaccine live attenuated) US prescribing information. Berna Products August, 2006.