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    Disopyramide/Selected Hydantoins

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    When these two medicines are taken together, your body may not process disopyramide properly.

    What might happen:

    You may experience an increase in the toxic effects and a decrease in the beneficial effects of disopyramide.

    What you should do about this interaction:

    Contact your doctor if you experience dry mouth, blurred vision, or decreased sweating.If your doctor prescribes these medicines together, it may be necessary to adjust your dose of disopyramide and measure your blood levels more often.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


    1.Aitio ML, Vuorenmaa T. Enhanced metabolism and diminished efficacy of disopyramide by enzyme induction?. Br J Clin Pharmacol 1980 Feb; 9(2):149-52.

    2.Aitio ML, Mansury L, Tala E, Haataja M, Aitio A. The effect of enzyme induction on the metabolism of disopyramide in man. Br J Clin Pharmacol 1981 Mar;11(3):279-85.

    3.Aitio ML. Plasma concentrations and protein binding of disopyramide and mono-N- dealkyldisopyramide during chronic oral disopyramide therapy. Br J Clin Pharmacol 1981 Apr;11(4):369-75.

    4.Matos JA, Fisher JD, Kim SG. Disopyramide - phenytoin interaction. Clin Res 1981;29(3):655A.

    5.Kessler JM, Keys PW, Stafford RW. Disopyramide and phenytoin interaction. Clin Pharm 1982 May-Jun;1(3):263-4.

    6.Nightingale J, Nappi JM. Effect of phenytoin on serum disopyramide concentrations. Clin Pharm 1987 Jan;6(1):46-50.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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