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Interactions

Cefuroxime axetil/H2 Blockers;PPIs

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

H2 blockers and proton pump inhibitors(PPIs) change the pH (acidity) your GI tract and may decrease the amount of cefuroxime that gets into your bloodstream.

What might happen:

Your antibiotic, may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you need to continue your H2 Blocker or proton pump inhibitor while you are taking cefuroxime for your infection, be sure to take each dose of cefuroxime after eating. A meal helps to increase the amount of cefuroxime that gets into your bloodstream.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Sommers DK, van Wyk M, Moncrieff J, Schoeman HS. Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil. Br J Clin Pharmacol 1984 Oct;18(4):535-9.

2.Ceftin (cefuroxime axetil) US prescribing information. GlaxoSmithKline January, 2010.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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