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    Voriconazole

    COMMON BRAND NAME(S): Vfend

    GENERIC NAME(S): voriconazole

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    Uses

    Voriconazole is used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals. It works by stopping the growth of fungi.

    How to use Voriconazole

    Read the Patient Information Leaflet if available from your pharmacist before you start taking voriconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    Take this medication by mouth without food (at least 1 hour before or 1 hour after meals) as directed by your doctor, usually every 12 hours.

    The dosage and length of treatment are based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

    For the best effect, take this antifungal at evenly spaced times. To help you remember, take this medication at the same times every day.

    Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

    Tell your doctor if your condition does not get better or if it gets worse.

    Side Effects

    Nausea/vomiting and headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if you have any serious side effects, including: vision changes (such as blurred vision, color vision changes), sensitivity of eyes to light (photophobia), eye pain, signs of kidney problems (such as change in the amount of urine), bone/joint pain, mental/mood changes (such as hallucinations).

    Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, severe dizziness, fainting.

    Voriconazole has rarely caused very serious (possibly fatal) liver disease. Tell your doctor right away if you develop symptoms of liver disease, such as: nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

    A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

    Voriconazole can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Get medical help right away if you develop any rash.

    This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

    In the US -

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

    In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

    Precautions

    Before taking voriconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (such as itraconazole); or if you have any other allergies. This product may contain inactive ingredients (such as lactose), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, heart problems (such as irregular heartbeat).

    Voriconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

    The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using voriconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

    Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using voriconazole safely.

    This drug may cause vision changes. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely. Do not drive at night.

    Avoid alcoholic beverages since they can increase the risk of serious liver problems.

    This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

    Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

    Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

    Children may be at greater risk for being more sensitive to the sun while using this drug (see above).

    Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using voriconazole. Voriconazole may harm an unborn baby. Ask about reliable forms of birth control while using this medication. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

    It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

    Interactions

    Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

    Voriconazole can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include eletriptan, ergot alkaloids (such as dihydroergotamine, ergotamine), certain drugs to treat irregular heartbeat (such disopyramide, dronedarone, quinidine), lurasidone, pimozide, ranolazine, sirolimus, certain "statin" cholesterol drugs (such as lovastatin, simvastatin), among others.

    Other medications can affect the removal of voriconazole from your body, which may affect how voriconazole works. Examples include efavirenz, rifamycins (such as rifabutin, rifampin), ritonavir, certain drugs used to treat seizures (such as carbamazepine, phenobarbital), St. John's wort, among others.

    Overdose

    If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

    Notes

    Do not share this medication with others.

    This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor directs you to do so. A different medication may be necessary in that case.

    Lab and/or medical tests (such as liver/kidney function, blood mineral levels) should be done before you start taking this medication and while you are taking it. Keep all medical and lab appointments. Consult your doctor for more details.

    Missed Dose

    If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. Do not double the dose to catch up.

    Storage

    Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

    Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised November 2016. Copyright(c) 2016 First Databank, Inc.

    Images

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    TEVA, 5290
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    V26
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    voriconazole 200 mg tablet
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    V 50
    voriconazole 200 mg tablet
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    V 200
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    283, S
    voriconazole 200 mg tablet
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    285, S
    voriconazole 50 mg tablet
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    G, VOR 50
    voriconazole 200 mg tablet
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    G, VOR200
    voriconazole 50 mg tablet
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    735
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet
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    736
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet
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    73, G
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet
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    oval
    imprint
    573, G
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    TEVA, 5289
    This medicine is a white, round, film-coated, tablet imprinted with "TEVA" and "5289".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oval
    imprint
    TEVA, 5290
    This medicine is a white, oval, film-coated, tablet imprinted with "TEVA" and "5290".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    oval
    imprint
    V26
    This medicine is a white, oval, film-coated, tablet imprinted with "V26".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oblong
    imprint
    M164
    This medicine is a white, oblong, film-coated, tablet imprinted with "M164".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    SZ, 132
    This medicine is a white, round, film-coated, tablet imprinted with "SZ" and "132".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oblong
    imprint
    SZ, 133
    This medicine is a white, oblong, film-coated, tablet imprinted with "SZ" and "133".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    V 50
    This medicine is a white, round, film-coated, tablet imprinted with "V 50".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oval
    imprint
    V 200
    This medicine is a white, oval, film-coated, tablet imprinted with "V 200".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    283, S
    This medicine is a white, round, film-coated, tablet imprinted with "283" and "S".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oblong
    imprint
    285, S
    This medicine is a white, oblong, film-coated, tablet imprinted with "285" and "S".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    G, VOR 50
    This medicine is a white, round, film-coated, tablet imprinted with "G" and "VOR 50".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oblong
    imprint
    G, VOR200
    This medicine is a white, oblong, film-coated, tablet imprinted with "G" and "VOR200".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    735
    This medicine is a white, round, film-coated, tablet imprinted with "735".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oval
    imprint
    736
    This medicine is a white, oval, film-coated, tablet imprinted with "736".
    voriconazole 50 mg tablet
    voriconazole 50 mg tablet

    Identification

    color
    white
    shape
    round
    imprint
    73, G
    This medicine is a white, round, film-coated, tablet imprinted with "73" and "G".
    voriconazole 200 mg tablet
    voriconazole 200 mg tablet

    Identification

    color
    white
    shape
    oval
    imprint
    573, G
    This medicine is a white, oval, film-coated, tablet imprinted with "573" and "G".

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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