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SMZ-TMP DS

Interactions

Cyclosporine/Sulfonamides

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of this interaction is not known. When these two medicines are taken together, you may be at risk for kidney damage.

What might happen:

Your blood levels of cyclosporine may decrease, which may decrease the effects of the medicine. Sulfonamides and cyclosporine taken together may cause kidney damage.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You may need to have your cyclosporine levels and your kidney function checked more often. Your doctor may need to change your antibiotic.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Thompson JF, Chalmers DH, Hunnisett AG, Wood RF, Morris PJ. Nephrotoxicity of trimethoprim and cotrimoxazole in renal allograft recipients treated with cyclosporine. Transplantation 1983 Aug;36(2):204-6.

2.Wallwork J, McGregor CG, Wells FC, Cory-Pearce R, English TA. Cyclosporin and intravenous sulphadimidine and trimethoprim therapy. Lancet 1983 Feb 12;1(8320):366-7.

3.Ringden O, Myrenfors P, Klintmalm G, Tyden G, Ost L. Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients. Lancet 1984 May 5;1(8384):1016-7.

4.Jones DK, Hakim M, Wallwork J, Higenbottam TW, White DJ. Serious interaction between cyclosporin A and sulphadimidine. Br Med J (Clin Res Ed) 1986 Mar 15;292(6522):728-9.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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