Skip to content

eplerenone

Interactions

Aldosterone Antagonists/Trimethoprim

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines can each raise the amount of potassium in your body.

What might happen:

Your blood levels of potassium may increase and cause breathing difficulties, chest pain, slow or irregular heartbeat, confusion, or muscle weakness.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may wish to change your medicine or have your potassium level monitored. Let your doctor know if you have any symptoms of a high potassium level.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Bactrim (sulfamethoxazole and trimethoprim) US prescribing information. Mutual Pharmaceutical Company, Inc. June, 2013.

2.Inspra (eplerenone) US prescribing information. Pfizer, Inc. May, 2013.

3.Aldactone (spironolactone) US prescribing information. Pfizer June, 2013.

4.Marinella MA. Trimethoprim-induced hyperkalemia: An analysis of reported cases. Gerontology 1999 Jul-Aug;45(4):209-12.

5.Velazquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Ann Intern Med 1993 Aug 15; 119(4):296-301.

6.Alappan R, Perazella MA, Buller GK. Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. Ann Intern Med 1996 Feb 1; 124(3):316-20.

7.Lam N, Weir MA, Juurlink DN, Gunraj N, Gomes T, Mamdani M, Hackam DG, Jain AK, Garg AX. Hospital admissions for hyperkalemia with trimethoprim-sulfamethoxazole: a cohort study using health care database codes for 393,039 older women with urinary tract infections. Am J Kidney Dis 2011 Mar;57(3):521-3.

8.Antoniou T, Gomes T, Mamdani MM, Yao Z, Hellings C, Garg AX, Weir MA, Juurlink DN. Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study. BMJ 2011;343:d5228.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices