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buprenorphine sublingual


Buprenorphine; Methadone/Boceprevir

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Boceprevir may affect how quickly your body processes buprenorphine and methadone.

What might happen:

The amount of buprenorphine or methadone in your blood may change. If it decreases, you may experience pain or withdrawal symptoms, such as nausea, vomiting, stomach pain, diarrhea, irritability, sleep disturbances. If it increases, you may experience excessive drowsiness, sluggishness, disorientation, shortness of breath, or difficulty breathing.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact your doctor if you experience an increase in pain, withdrawal symptoms, or if you experience any signs of excessive drowsiness, sluggishness, disorientation, shortness of breath, or difficulty breathing. Your doctor may want to adjust the dose of your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Victrelis (boceprevir) US prescribing information. Schering Corporation February, 2014.


Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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