Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The exact mechanism is unknown but may be a result of additive serum glucose lowering.(1)
What might happen:
Taking repaglinide and NPH insulin together may increase your risk of low blood sugar and heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction).
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you have swollen legs or ankles, unexplained weight gain, difficulty breathing, unusual tiredness or changes in vision.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Prandin (repaglinide) US prescribing information. Novo Nordisk Pharmaceuticals, Inc. June, 2009.