Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process lithium properly.
What might happen:
Your blood levels of lithium may increase and cause toxic effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you experience new or worsened hand tremors, fatigue, muscle weakness or unusual stiffness, confusion, slurred speech, vomiting, diarrhea, loss of appetite, blurred vision, trouble walking, ringing in the ears, seizures, dizziness, or heart palpitations call your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Keep all of your appointments with the doctor and laboratory. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Inspra (eplerenone) US prescribing information. Pfizer Inc. March, 2011.
2.Aldactone (spironolactone) US prescribing information. Searle Division of Pfizer August, 2011.
3.Lithobid (lithium carbonate) US prescribing information. Noven Therapeutics, LLC October, 2011.