How the interaction occurs:
Deferasirox may slow down how quickly your liver processes theophylline or tizanidine.
What might happen:
The amount of theophylline or tizanidine in your blood may increase, and may increase your risk for toxic effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together.Let your doctor know if you have any fainting or dizziness episodes, or extreme fatigue. Your doctor may want to change the dose of your tizanidine. Use caution when performing tasks that require alertness.If you experience nausea, vomiting, diarrhea, headache, irritability, a fast heartbeat, or are unable to sleep, contact your doctor. It may be necessary to adjust the dose of your theophylline.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Exjade (deferasirox) US prescribing information. Novartis Pharmaceuticals Corporation October, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.