Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The liquid form of amprenavir contains propylene glycol. Disulfiram decreases your body's ability to process propylene glycol.
What might happen:
Levels of propylene glycol may build up in your body. This may cause seizures, confusion, a fast heartbeat, or problems with your kidneys or blood.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Dear Healthcare Professional letter. RE: Potential safety concerns with the large amount of propylene glycol in AGENERASE (amprenavir) oral solution. Glaxo Wellcome, Inc. May, 2000.
2.Agenerase (amprenavir) Oral Solution US prescribing information. GlaxoSmithKline May, 2005.