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Cortef

Interactions

Hydrocortisone, Oral/Bile Acid Sequestrants

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the amount of hydrocortisone absorbed by your body may decrease.

What might happen:

You may experience a decrease in the beneficial effects of hydrocortisone.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to increase your dose of hydrocortisone or to change the time you take one or both medicines. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Ware AJ, Combes B. Influence of sodium taurocholate, cholestyramine, and mylanta on the intestinal absorption of glucocorticoids in the rat. Gastroenterology 1973 Jun;64(6):1150-5.

2.Johansson C, Adamsson U, Stierner U, Lindsten T. Interaction by cholestyramine on the uptake of hydrocortisone in the gastrointestinal tract. Acta Med Scand 1978;204(6):509-12.

3.Nekl KE, Aron DC. Hydrocortisone-colestipol interaction. Ann Pharmacother 1993 Jul-Aug;27(7-8):980-1.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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