Skip to content

Estrace

Interactions

Selected Anticonvulsants/Estrogens

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body processes estrogens more quickly.

What might happen:

A decrease in the beneficial effects of your estrogens may occur. Your risk for osteoporosis may increase.

What you should do about this interaction:

If you experience spotting, breakthrough bleeding, or vaginal pain, contact your doctor. It may be necessary to increase the dose of your medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Janz D, Schmidt D. Letter: Anti-epileptic drugs and failure of oral contraceptives. Lancet 1974 Jun 1;1(7866):1113.

2.Laengner H, Detering K. Letter: Anti-epileptic drugs and failure of oral contraceptives. Lancet 1974 Sep 7;2(7880):600.

3.Hempel E, Klinger W. Drug stimulated biotransformation of hormonal steroid contraceptives: clinical implications. Drugs 1976 Dec;12(6):442-8.

4.Roberton YR, Johnson ES. Interactions between oral contraceptives and other drugs: a review. Curr Med Res Opin 1976;3(9):647-61.

5.Coulam CB, Annegers JF. Do anticonvulsants reduce the efficacy of oral contraceptives?. Epilepsia 1979 Oct;20(5):519-25.

6.Back DJ, Bates M, Bowden A, Breckenridge AM, Hall MJ, Jones H, MacIver M, Orme M, Perucca E, Richens A, Rowe PH, Smith E. The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy. Contraception 1980 Nov;22(5):495-503.

7.Anonymous. Drug interaction with oral contraceptive steroids. Br Med J 1980 Jul 12;281(6233):93-4.

8.Mattson RH, Cramer JA, Darney PD, Naftolin F. Use of oral contraceptives by women with epilepsy. JAMA 1986 Jul 11;256(2):238-40.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices