Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process midazolam or triazolam properly.
What might happen:
Your blood levels of midazolam or triazolam may increase and cause more drowsiness or difficulty breathing.
What you should do about this interaction:
Talk to your healthcare professionals (e.g. doctor or pharmacist) as soon possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sustiva (efavirenz) US prescribing information. Bristol-Myers Squibb Company August, 2012.
2.Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. October, 2013.