Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
You may experience an increase in the toxic effects of these medicines.
What you should do about this interaction:
If you experience confusion, fever, tremors, weakness, sluggishness, mental or mood changes, or other symptoms, contact your doctor. It may be necessary to monitor your treatment more closely or to change you to a different medicine.High doses of one or both medicines, previous problems with your brain, a history of similar symptoms caused by medicines in the past, or other current diseases such as infection or dehydration may increase the chance for harmful effects.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Cohen WJ, Cohen NH. Lithium carbonate, haloperidol, and irreversible brain damage. JAMA 1974 Dec 2;230(9):1283-7.
2.Thornton WE, Pray BJ. Lithium intoxication: a report of two cases. Can Psychiatr Assoc J 1975 Jun;20(4):281-2.
3.Loudon JB, Waring H. Toxic reactions to lithium and haloperidol. Lancet 1976 Nov 13;2(7994):1088.
4.Baastrup PC, Hollnagel P, Sorensen R, Schou M. Adverse reactions in treatment with lithium carbonate and haloperidol. JAMA 1976 Dec 6; 236(23):2645-6.
5.Juhl RP, Tsuang MT, Perry PJ. Concomitant administration of haloperidol and lithium carbonate in acute mania. Dis Nerv Syst 1977 Sep;38(9):675-6.
6.Thomas CJ. Brain damage with lithium/haloperidol. Br J Psychiatry 1979 May;134:552.
7.Biederman J, Lerner Y, Belmaker RH. Combination of lithium carbonate and haloperidol in schizo-affective disorder: a controlled study. Arch Gen Psychiatry 1979 Mar;36(3):327-33.
8.Thomas C, Tatham A, Jakubowski S. Lithium/haloperidol combinations and brain damage. Lancet 1982 Mar 13;1(8272):626.
9.Spring G, Frankel M. New data on lithium and haloperidol incompatibility. Am J Psychiatry 1981 Jun;138(6):818-21.
10.Addonizio G. Rapid induction of extrapyramidal side effects with combined use of lithium and neuroleptics. J Clin Psychopharmacol 1985 Oct; 5(5):296-8.
11.Goldney RD, Spence ND. Safety of the combination of lithium and neuroleptic drugs. Am J Psychiatry 1986 Jul;143(7):882-4.
12.Saran A, Addy O, Foliart RH, Schubert DS, Halaris A. Electroencephalographic changes and other indices of neurotoxicity with haloperidol-lithium therapy. Neuropsychobiology 1989;20(3):152-7.