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Inderide

Interactions

Lidocaine/Beta-Blockers

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process lidocaine properly.

What might happen:

An increase in the toxic effects of lidocaine may occur.

What you should do about this interaction:

If you experience confusion, blurred vision, nausea, vomiting, weakness, fatigue, dizziness, drowsiness, or slow heartbeat, contact your doctor. Your doctor may need to check the blood levels of lidocaine and adjust the dose of your medicine. This interaction may be worse if you are on propranolol or metoprolol.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Ochs HR, Carstens G, Greenblatt DJ. Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol. N Engl J Med 1980 Aug 14;303(7):373-7.

2.Graham CF, Turner WM, Jones JK. Lidocaine-propranolol interactions. N Engl J Med 1981 May 21;304(21):1301.

3.Conrad KA, Byers JM, Finley PR, Burnham L. Metoprolol reduces lidocaine elimination. Clin Pharm Ther 1982 Feb;31(2):212.

4.Schneck DW, Luderer JR, Davis D, Vary J. Effects of nadolol and propranolol on plasma lidocaine clearance. Clin Pharmacol Ther 1984 Nov; 36(5):584-7.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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