Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Taking levothyroxine and ciprofloxacin at the same time may decrease the amount levothyroxine in your body.
What might happen:
Your levothyroxine may not work as well. Signs and symptoms to look for include: feeling tired, dry skin and brittle nails,and not being able to stand the cold, constipation, depression.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You may need to separate the times you take your levothyroxine and ciprofloxacin.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Goldberg AS, Tirona RG, Asher LJ, Kim RB, Van Uum SH. Ciprofloxacin and rifampin have opposite effects on levothyroxine absorption. Thyroid 2013 Nov;23(11):1374-8.
2.Cooper JG, Harboe K, Frost SK, Skadberg O. Ciprofloxacin interacts with thyroid replacement therapy. BMJ 2005 Apr 30;330(7498):1002.