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Tagamet

Interactions

Carmustine/Cimetidine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. Cimetidine may increase the effects of carmustine.

What might happen:

An increase in the toxic effects of one or both medicines may occur.

What you should do about this interaction:

If you experience easy bruising or bleeding, persistent sore throat, fever, or fatigue, contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Anonymous. Alternative mechanisms for severe neutropenia. Arch Intern Med 1982 Oct;142(10):1971.

2.Selker RG, Moore P, Lodolce D. Bone-marrow depression with cimetidine plus carmustine. N Engl J Med 1978 Oct 12;299(15):834.

3.Volkin RL, Shadduck RK, Winkelstein A, Zeigler ZR, Selker RG. Potentiation of carmustine-cranial irradiation-induced myelosuppression by cimetidine. Arch Intern Med 1982 Feb;142(2):243-5.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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