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Trandate

Interactions

Beta-Blockers/Food Interaction

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.

Medical warning:

Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.

How the interaction occurs:

When food is taken with this beta-blocker medicine, the amount of medicine in your bloodstream may be higher than if it is taken on an empty stomach. It is not clear why this is true. It may be due to an increase in the amount of medicine you absorb into your bloodstream or a decrease in the speed at which your body processes (metabolizes) it.

What might happen:

Your blood levels of this medicine may increase.

What you should do about this interaction:

Always take this medicine with meals or always take it on an empty stomach (one hour before or two hours after food). This will help you to avoid unwanted changes in the level of this medicine in your blood. Contact your healthcare professional (e.g., doctor or pharmacist) for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.

References:

1.McLean AJ, Isbister C, Bobik A, Dudley FJ. Reduction of first-pass hepatic clearance of propranolol by food. Clin Pharmacol Ther 1981 Jul;30(1):31-4.

2.Walle T, Fagan TC, Walle UK, Oexmann MJ, Conradi EC, Gaffney TE. Food-induced increase in propranolol bioavailability--relationship to protein and effects on metabolites. Clin Pharmacol Ther 1981 Dec; 30(6):790-5.

3.Naranjo CA, Sellers EM, Khouw V. Unaltered serum propranolol binding by meal-induced variations in fatty acids. Br J Clin Pharmacol 1982 Apr; 13(4):575-6.

4.Melander A, Danielson K, Schersten B, Wahlin E. Enhancement of the bioavailability of propranolol and metoprolol by food. Clin Pharmacol Ther 1977 Jul;22(1):108-12.

5.Daneshmend TK, Roberts CJ. The influence of food on the oral and intravenous pharmacokinetics of a high clearance drug: a study with labetalol. Br J Clin Pharmacol 1982 Jul;14(1):73-8.

6.Byrne AJ, McNeil JJ, Harrison PM, Louis W, Tonkin AM, McLean AJ. Stable oral availability of sustained release propranolol when co-administered with hydralazine or food: evidence implicating substrate delivery rate as a determinant of presystemic drug interactions. Br J Clin Pharmacol 1984; 17 Suppl 1:45S-50S.

7.Olanoff LS, Walle T, Cowart TD, Walle UK, Oexmann MJ, Conradi EC. Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis. Clin Pharmacol Ther 1986 Oct;40(4):408-14.

8.Shand DG, Nuckolls EM, Oates JA. Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther 1970 Jan-Feb; 11(1):112-20.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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