How the interaction occurs:
When these two medicines are taken together, your body may not process potassium properly.
What might happen:
Your blood levels of potassium may increase and cause breathing difficulties, chest pain, slow or irregular heartbeat, confusion, or muscle weakness. This interaction may be more severe if you are taking eplerenone for high blood pressure.
What you should do about this interaction:
Contact your healthcare professional (e.g. doctor or pharmacist) as soon as possible about taking these medicines together. Your doctor may want to check the amount of potassium in your blood.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Inspra (eplerenone) US prescribing information. Pfizer, Inc. May, 2013.
2.Aldactone (spironolactone) US prescribing information. Pfizer June, 2013.