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Reyataz

Interactions

Selected Antimuscarinics/Strong CYP3A4 Inhibitors

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may prevent your body from processing your overactive bladder medicine correctly.

What might happen:

The levels of overactive bladder medicine in your blood may increase. You may notice an increase in side effects, such as blurred vision, dizziness, drowsiness, dry mouth, upset stomach, headache, dry eyes, or constipation.

What you should do about this interaction:

If you notice an increase in any side effects from your medicine, contact your healthcare professional (e.g. doctor or pharmacist). Your doctor may want to decrease the dose of your overactive bladder medicine while you are taking your other medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Enablex (darifenacin) US prescribing information. Warner Chilcott (US), LLC March, 2012.

2.Toviaz (fesoterodine fumarate) US prescribing information. Pfizer August, 2012.

3.Vesicare (solifenacin succinate) US prescribing information. Astella Pharma US, Inc. October, 2013.

4.Urizia (tamsulosin-solifenacin) Swedish prescribing information. Astellas Pharma December 5, 2013.

5.Detrol (tolterodine tartrate) US prescribing information. Pfizer Inc. August, 2012.

6.Detrol LA (tolterodine tartrate) US prescribing information. Pfizer Inc. August, 2012.

7.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.

8.Malhotra B, Dickins M, Alvey C, Jumadilova Z, Li X, Duczynski G, Gandelman K. Effects of the Moderate CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fesoterodine in Healthy Subjects. Br J Clin Pharmacol 2011 May 5.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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