Ethacrynate sodium is used to decrease swelling (edema) caused by conditions such as cancer, congestive heart failure, liver disease, and kidney disease. This medication works in your kidneys like a "water pill"/diuretic to increase the amount of urine you make. This effect can help your kidneys work better and lessen symptoms such as trouble breathing and swelling in your ankles, feet, hands, or belly.
This medication should not be used for infants.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication is given by injection into a vein as directed by your doctor. It is usually given by a health care professional.
The dosage is based on your medical condition and response to treatment. Your doctor will adjust your dose based on your medical condition, response to treatment, and lab tests (such as sodium, potassium, chloride levels).
If you use this drug too close to bedtime, you may need to wake up to urinate. It is best to use this medication at least 4 hours before your bedtime. Consult your doctor or pharmacist if you have questions about your dosing schedule.
Tell your doctor if you do not get better or if you get worse.
Pain at the injection site, dizziness, lightheadedness, weakness, muscle cramps, upset stomach, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This drug can cause a serious loss of body water (dehydration) and salt/minerals. Tell your doctor right away if you notice any symptoms of dehydration, such as confusion, unusual decreased urination, unusual dry mouth/thirst, fast/irregular heartbeat, or severe dizziness/lightheadedness.
Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, feeling of spinning (vertigo), hearing changes (such as ringing or fullness in the ears, decreased hearing/deafness), black/bloody stools, stomach/abdominal pain, vomit that looks like coffee grounds, signs of liver problems (such as nausea/vomiting that doesn't stop, loss of appetite, yellowing eyes/skin, dark urine).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using ethacrynate sodium, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.
This drug can lower certain salt/mineral levels (such as sodium, potassium) in your blood. Your doctor may tell you to use more salt, eat potassium-rich foods (such as bananas, orange juice), or take a potassium supplement. Ask your doctor for more details.
This medication may affect your blood sugar level. If you have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your anti-diabetic medication, exercise program, or diet.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug, especially dizziness and water/mineral loss.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: furosemide, lithium.
Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure or worsen swelling (edema). Ask your pharmacist for more details.
If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Lab and/or medical tests (such as kidney tests, blood mineral levels such as potassium) should be done while you are taking this medication. Keep all medical and lab appointments.
Not applicable. This medication is given in a hospital or clinic and will not be stored at home.
Information last revised January 2016. Copyright(c) 2016 First Databank, Inc.
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