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Interactions

Chloroquine; Hydroxychloroquine/Di-; Trivalent Cations

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken at the same time, they may bind together in your GI tract.

What might happen:

Your medicines may not work as well.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. If your doctor prescribes these medicines together, take them at least two to four hours apart. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Khalil SA. Effect of chloroquine adsorption on acid reactivity of magnesium trisilicate. J Pharm Sci 1977 Feb;66(2):289-90.

2.Fosrenol (lanthanum carbonate) Canadian prescribing information. Shire BioChem February 19, 2007.

3.McElnay JC, Mukhtar HA, D'Arcy PF, Temple DJ, Collier PS. The effect of magnesium trisilicate and kaolin on the in vivo absorption of chloroquine. J Trop Med Hyg 1982 Aug;85(4):159-63.

4.Iwuagwu MA, Aloko KS. Adsorption of paracetamol and chloroquine phosphate by some antacids. J Pharm Pharmacol 1992 Aug;44(8):655-8.

5.McElnay JC, Mukhtar HA, D'Arcy PF, Temple DJ. In vitro experiments on chloroquine and pyrimethamine absorption in the presence of antacid constituents or kaolin. J Trop Med Hyg 1982 Aug;85(4):153-8.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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